A cystine knot is a protein structural motif containing three disulfide bridges. The sections of polypeptide that occur between two of them form a loop through which a third disulfide bond passes, forming a rotaxane-like substructure. The cystine knot motif stabilizes protein structure and is conserved in proteins across various species. There are three types of cystine knot, which differ in the topology of the disulfide bonds:
- Growth factor cystine knot (GFCK) \n
- Inhibitor cystine knot (ICK), common in spider and snail toxins \n
- Cyclic cystine knot, or cyclotide
{"fact":"According to Hebrew legend, Noah prayed to God for help protecting all the food he stored on the ark from being eaten by rats. In reply, God made the lion sneeze, and out popped a cat.","length":184}
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{"type":"standard","title":"Triosephosphate isomerase","displaytitle":"Triosephosphate isomerase","namespace":{"id":0,"text":""},"wikibase_item":"Q24777683","titles":{"canonical":"Triosephosphate_isomerase","normalized":"Triosephosphate isomerase","display":"Triosephosphate isomerase"},"pageid":2385420,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/f/fb/TriosePhosphateIsomerase_Ribbon_pastel_trans.png/330px-TriosePhosphateIsomerase_Ribbon_pastel_trans.png","width":320,"height":240},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/f/fb/TriosePhosphateIsomerase_Ribbon_pastel_trans.png","width":1600,"height":1200},"lang":"en","dir":"ltr","revision":"1266901419","tid":"f9a06561-c93d-11ef-ab00-993ef32d5ec0","timestamp":"2025-01-02T19:15:49Z","description":"Enzyme involved in glycolysis","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Triosephosphate_isomerase","revisions":"https://en.wikipedia.org/wiki/Triosephosphate_isomerase?action=history","edit":"https://en.wikipedia.org/wiki/Triosephosphate_isomerase?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Triosephosphate_isomerase"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Triosephosphate_isomerase","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Triosephosphate_isomerase","edit":"https://en.m.wikipedia.org/wiki/Triosephosphate_isomerase?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Triosephosphate_isomerase"}},"extract":"Triose-phosphate isomerase is an enzyme that catalyzes the reversible interconversion of the triose phosphate isomers dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate.","extract_html":"
Triose-phosphate isomerase is an enzyme that catalyzes the reversible interconversion of the triose phosphate isomers dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate.
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